Pearls from Dr. Suneeta Krishnareddy

20 y/o M hx of UC who p/w bloody diarrhea - C. Diff and UC Flare

2016-10-25

  • Differential of Bloody Diarrhea

    Posted 10/25/16 09:03:05 AM by Ying Liu

  • Indicators of UC Disease Severity (Truelove Witts Table)

    Posted 10/25/16 09:04:57 AM by Ying Liu

  • Infection in UC

    Posted 10/25/16 09:07:54 AM by Ying Liu

  • Induction Therapy for Severe/Fulminant UC (in addition to steroids)

    Posted 10/25/16 09:11:21 AM by Ying Liu

  • Indications for Colectomy 
    NOTE: Would scope and biopsy prior to surgery to confirm diagnosis as preferred surgery for UC is J-pouch to preserve rectal function, but this surgery is terrible for Crohn's. This is one instance where serologies have utility.



    Posted 10/25/16 09:13:59 AM by Ying Liu

  • Miscellaneous

    Posted 10/25/16 09:14:59 AM by Ying Liu

  • 73 y/o with UC presenting with EPEC and UC flare, found to also have NSCLC

    2017-02-14

  • IBD Epidemiology:
    The age of onset of most cases of UC and Crohn disease is between 15 and 40 years. There does seem to be a bimodal age distribution for both disorders with a possible second peak between 50 and 80 years.
    -Current smoking can have a protective effect for UC...however cessation of smoking seems to increase disease activity in UC

    Posted 02/14/17 05:45:28 PM by Adam Faye

  • 5-ASA in UC:

    Pearl:
    Budesonide will not work in UC because it acts in small intestine, not in the colon. There is a formulation that works in the colon but very expensive.

    Posted 02/14/17 05:47:38 PM by Adam Faye

  • Addition of Loperamide?

    Posted 02/14/17 05:48:55 PM by Adam Faye

  • TNF therapy in UC:

    Infliximab + Azathioprine achieved remission in UC better than montherapy:

    Posted 02/14/17 05:56:17 PM by Adam Faye

  • Vedolizumab as induction and maintenance therapy for UC:

    Induction Therapy: 374 pts. Received Vedolizumab vs. 521 patients received placebo at weeks 0 and 2. Eval disease activity at week 6.

    Patients who had a response by week 6 -> randomized to placebo or Vedolizumab every 4/8 weeks for up to 1 year. 

    Posted 02/14/17 05:57:37 PM by Adam Faye


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