• Peritoneal Mets in Colorectal Cancer is a poor prognostic marker
  • Stage 4- previously only treated with 5-FU with high mortality at 6 months.
  • Newer agents such as Irinotecan/Oxaliplatin added to 5-FU and Lecuovorin now have improved prognosis - median survival closer to 30 months. 
  
  

  Posted 09/06/16 04:12:18 PM by Adam Faye

• If pt. has WT KRAS mutation- can be considered for anti-EGFR therapy (Panitumumab) - has been shown to improve survival.
  Staging is the most accurate predictor of outcome in pts. with colorectal cancer.
  
  

  Posted 09/06/16 04:19:47 PM by Adam Faye

• Staging Colorectal Cancer:
  • CEA- useful for response to therapy/recurrence. In general, tumor markers better for prognosis/recurrence than diagnosis
  • CT Chest, Abdomen, Pelvis. Often see colorectal mets in the liver
  • CRC is one of the few malignancies that can be surgically removed even if there are mets (generally only if the mets are isolated to one organ system). 
  
  

  Posted 09/06/16 04:23:19 PM by Adam Faye

• FOLFIRI followed by FOLFOX or the Reverse Sequence in Colorectal Cancer
  Aspirin Use and Survival After Diagnosis of Colorectal Cancer
  
  

  Posted 09/06/16 04:28:19 PM by Adam Faye

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