-
In Acute Leukemia- neutrophils are not functioning properly (Thus, even if ANC > 1,500 because of leukocytosis neutrophil function still impaired).
Posted 08/01/16 04:51:16 PM by Adam Faye
-
Transfusion practices in Acute Leukemia:
In acute leukemia likely will have thrombocytopenia/anemia - often important to transfuse. However, be cautious if WBC >50-100,000 with many blasts- can lead to leukostasis and acute decompensation.
- Signs and Symptoms
- Pulm- Dyspnea/hypoxia
- Neuro- Visual changes, HA, dizziness, tinnitus, gait instability, confusion, somnolence
- Treat with cytoreduction - chemo/hydrea/leukapheresis (be cautious of precipitating TLS)
Posted 08/01/16 04:57:33 PM by Adam Faye
-
When treating AML: In those <55, time to chemo has a mortality benefit:
- Induction Chemo - Cytarabine with an Anthracycline
- If there is an underlying infection you cannot control in acute leukemia you should NOT go ahead with chemotherapy
- High Fibrinogen does NOT necessarily r/o DIC
Prognosis:
- FISH analysis showing deletions on 1/3 and in conjunction with 5/7 offer very poor prognosis
Posted 08/01/16 05:03:11 PM by Adam Faye
-
For further reading...
Posted 08/01/16 05:03:30 PM by Adam Faye