Nephrotic syndrome - refers to a distinct entity with clinical and laboratory features consisting of:
- Nephrotic range proteinuria - greater than 3.5g/24 hours
- Hypoalbuminemia - less than 3g/dL
- Peripheral edema
Hyperlipidemia and thrombotic disease are also frequently observed as part of the nephrotic syndrome but not required to meet the definition
Posted 07/21/16 10:06:45 AM by Anna Krigel
Posted 07/21/16 10:16:03 AM by Anna Krigel
Etiologies of nephrotic syndrome in adults
- About 30% of adults will have a systemic disease like:
- Remainder of cases usually due to primary renal disorders like:
- Minimal change disease - most common cause of idiopathic nephrotic syndrome in children
- Focal segmental glomerulosclerosis (FSGS) - accounts for 50% of cases of idiopathic nephrotic syndrome in African-American patients
- Membranous nephropathy - can be primary or secondary to HBV, HCV, SLE, NSAIDS, syphilis, malignancy, and multiple other associations
Posted 07/21/16 10:29:35 AM by Anna Krigel
Created by Christopher Kelly
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