Evaluating acute kidney injury
- Always get renal ultrasound in older men presenting with AKI, especially if there is a history of BPH
- Hematuria + proteinuria + renal failure usually represents glomerulonephritis
- Absence of white cells in urine makes acute/chronic interstitial nephritis unlikely
Causes of glomerulonephritis
- Low complement: post-infectious, SLE, MPGN, cryoglobulinemia
- Normal complement: IgA nephropathy, ANCA vasculitis, anti-GBM disease
- ANCA and anti-GBM vasculitis usually diagnosed on biopsy with pauci-immune and linear staining, respectively, on immunoflorescence
- One of the most common symptoms = general malaise
- Relapse rate higher with PR3-ANCA versus MPO-ANCA, highest when lung involvement is present
- Very elevated ANCA titers (> 500) usually associated with drug-induced ANCA vasculitis
Posted 06/27/17 04:20:19 PM by Iheanacho (Obi) Emeruwa
Created by Christopher Kelly
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