Differential diagnosis of nephrotic syndrome in the US:
- Idiopathic causes
- Minimal change disease - most common cause in children, the cause in 10-15% of adults, though more common in those with autoimmune disease
- Focal segmental glomerulosclerosis - most common in African-Americans
- Membranous nephropathy - most common in Caucasians
- Secondary causes
- Diabetes - most common cause of nephrotic syndrome in the United States
- SLE - can cause MPGN
- Collagen diseases
- Infection-related causes - HIV, HBV, HCV, malaria
- Medications - NSAIDS most common
- Thrombotic microangiopathies
Posted 06/30/16 09:15:26 AM by Anna Krigel
Check for compliments!! Only four causes of nephrotic syndrome that result in hypocomplimentemia:
- Idiopathic (C3 nephropathy)
Posted 06/30/16 09:17:53 AM by Anna Krigel
Classic signs and symptoms of nephrotic syndrome:
Posted 06/30/16 09:23:39 AM by Anna Krigel
Amyloidosis - accounts for 4-17% of cases of seemingly idiopathic nephrotic syndrome
- Two major types
- AL or primary amyloid - monoclonal light chains form the amyloid fibrils
- AA or secondary amyloid - acute phase reactant serum amyloid A forms the amyloid fibrils
- associated with chronic inflammatory diseases such as RA/juvenile RA, spondyloarthropathies/psoriasis, IBD, FMF, or idiopathic causes
- Detected on biopsy using congo red dye for staining - will see apple-green birefringence
Posted 06/30/16 10:33:36 AM by Anna Krigel
For further reading...
Posted 06/30/16 10:57:42 AM by Anna Krigel
Created by Christopher Kelly
Know a hypochondriac? Get them the best-selling book 'AM I DYING?!: A Complete Guide to Your Symptoms, and What to Do Next'
The information on the website does not constitute official guidelines except where explicitly stated.
It is not meant to replace the advice of a health professional.