• Candida esophagitis
  • One of the most common opportunistic infections in AIDS
  • Occurs rapidly when CD4 count < 200
  • Other populations: solid organ transplant, stem cell transplant, CVID
  • Not commonly seen in patients on chronic steroids
  • Rare cause of candidemia
  
  HIV testing
  • Antigen/antibody includes p24 antigen, which narrows window period between infection and diagnosis
    • Very high sensitivity  (> 99%)!
  • Geenius test delineates between HIV 1 and HIV 2 (HIV 1 much more common in the United States)
  
  Initial therapies for HIV infection
  • Think of 2 NRTIs as backbone of regimen
  • Can include an NNRTI, boosted protease inhibitor, or integrase inhibitor
  • Integrase inhibitor resistance almost non-existent!
  
  
  
  

  Posted 06/20/17 12:53:58 AM by Iheanacho (Obi) Emeruwa

• For further reading...

  Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry.
  Invasive Candidiasis
  Acute HIV-1 Infection
  Antiretroviral Therapy Initiated Within 6 Months of HIV Infection Is Associated With Lower T-Cell Activation and Smaller HIV Reservoir Size
  Abacavir–Lamivudine versus Tenofovir–Emtricitabine for Initial HIV-1 Therapy
  
  

  Posted 06/20/17 01:01:00 AM by Iheanacho (Obi) Emeruwa

Created by Christopher Kelly

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