-
MAC - Mycobacterium avium complex in HIV-infected patients
- Infection caused by one of two nontuberculous mycobacterial species:
- M. avium
- M. intracellulare
- Organisms are ubiquitous in the environment, including water and soil
- Risk of MAC infection in patients with CD4 count <50
- Azithromycin used for prophylaxis when CD4 count <50
- Prophylaxis typically stopped when CD4 count recovers to >100
- Signs/symptoms of disseminated MAC - fever, night sweats, abdominal pain, diarrhea, weight loss
- Treatment consists of either clarithromycin or azithromycin as the cornerstone of treatment typically with ethambutol+rifabutin
Posted 04/27/17 09:37:02 AM by Anna Krigel
-
IRIS - Immune Reconstitution Inflammatory Syndrome
- Generally accepted to be:
- Worsening of a recognized infection ("paradoxical" IRIS)
- Or, worsening of an unrecognized pre-existing infection ("unmasking" IRIS)
- Features that should be present for a diagnosis of IRIS
- AIDS with low pre-treatment CD4 count (often <100)
- Positive immunologic response to ART
- Clinical manifestations consistent with an inflammatory condition
- Temporal association between HAART initiation and onset of clinical features of illness
- Pathogens associated with IRIS
- Mycobacterium tuberculosis
- MAC
- CMV
- Cryptococcus
- Pneumocystis
- HSV
- HBV
- HHV8
Posted 04/27/17 09:51:28 AM by Anna Krigel
-
For further reading...
Posted 04/27/17 09:54:38 AM by Anna Krigel
Created by Christopher Kelly
Know a hypochondriac? Get them the best-selling book 'AM I DYING?!: A Complete Guide to Your Symptoms, and What to Do Next'
The information on the website does not constitute official guidelines except where explicitly stated.
It is not meant to replace the advice of a health professional.