MAC - Mycobacterium avium complex in HIV-infected patients
- Infection caused by one of two nontuberculous mycobacterial species:
- M. avium
- M. intracellulare
- Organisms are ubiquitous in the environment, including water and soil
- Risk of MAC infection in patients with CD4 count <50
- Azithromycin used for prophylaxis when CD4 count <50
- Prophylaxis typically stopped when CD4 count recovers to >100
- Signs/symptoms of disseminated MAC - fever, night sweats, abdominal pain, diarrhea, weight loss
- Treatment consists of either clarithromycin or azithromycin as the cornerstone of treatment typically with ethambutol+rifabutin
Posted 04/27/17 09:37:02 AM by Anna Krigel
IRIS - Immune Reconstitution Inflammatory Syndrome
- Generally accepted to be:
- Worsening of a recognized infection ("paradoxical" IRIS)
- Or, worsening of an unrecognized pre-existing infection ("unmasking" IRIS)
- Features that should be present for a diagnosis of IRIS
- AIDS with low pre-treatment CD4 count (often <100)
- Positive immunologic response to ART
- Clinical manifestations consistent with an inflammatory condition
- Temporal association between HAART initiation and onset of clinical features of illness
- Pathogens associated with IRIS
- Mycobacterium tuberculosis
Posted 04/27/17 09:51:28 AM by Anna Krigel
For further reading...
Posted 04/27/17 09:54:38 AM by Anna Krigel
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