• Staphylococci Aureus
  • Characteristics: Gram positive cocci in clusters, coag positive, catalase positive.  Gold colonies.
  • Habitat: human nose also skin
  • Diseases
    • Non-toxin related
      • Osteomyelitis
      • Endocarditis
      • Septic arthritis
      • Meningitis
      • PNA
      • Skin and wound infections
      • Impetigo
    • Toxin related
      • Toxic shock syndrome
      • Food poisoning
      • Scalded skin syndrome 
  
  

  Posted 03/29/17 10:13:53 PM by Ying Liu

• Management Pearls
  • S. Aureus have a high proprensity for metastatic disease so must be vigillant, especially if cultures are persistently positive. High rates of endocarditis associated with peripheral IV infections. S. Aureus can also form biofilms
  • MRSA bacteremia is likely from carriage, and although nasal swabs are great, there are other sites of potential colonization
  • Firstline therapy for MRSA is Vancomycin, but there are many mechanisms for resistance. Check MIC as most common mechanism is called MIC Creep
  • 2nd-line is often a combination of ceftaroline and daptomycin
  
  

  Posted 03/29/17 10:19:11 PM by Ying Liu

• For further reading...

  From our very own Dr. Lowy 
  
  

  Posted 03/29/17 10:19:54 PM by Ying Liu

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