•  Pericardial effusion: reported in 30% to 80% of subjects with hypothyroidism 
  • Usually associated with severity of disease
  • Exudative
  • Tamponade rare as effusions typically slow growing and rarely large
  • Responsive to thyroid hormone replacement
  
  
  
  

  Posted 03/02/17 09:13:20 AM by Matthew Cummings

• Severe hypothyroidism and risk of adrenal insufficiency
  • Primary hypothyroidism --> risk of primary AI; secondary hypothyroidism --> hypopituitarism and secondary AI. 
    • Potential risk of precipitating acute adrenal insufficiency caused by the accelerated metabolism of cortisol that follows T4 therapy.
  • Send AM cortisol, low threshold for stress dose hydrocortisone
  
  

  Posted 03/02/17 09:19:30 AM by Matthew Cummings

• For further reading...

  Thyroid disease and the heart (Circulation 2007)
  Pericardial effusion in primary hypothyroidism (Am J Heart 1990)
  
  
  
  

  Posted 03/02/17 09:22:20 AM by Matthew Cummings

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