• Nesiritide for acute heart failure:
  • 7141 patients with acute heart failure; Nesiritide vs. Placebo
    • Primary Endpoint- Change in dyspnea at 6 & 24hrs.
    • 6hrs- 44.5% vs. 42.1% & 24hrs- 68.2% vs. 66.%1
    • No difference in readmission/death/rate of worsening renal function at 30 days. 
  
  

  Posted 02/22/17 01:49:13 PM by Adam Faye

• IgG4 Related Disease:
  • Typically have high serum IgG4 levels
  • On histopathology see IgG4-positive lymphoplasmacytic infiltration, fibrosis, and obliterative phlebitis or arteritis.
  • Men:Women - 3:1 likelihood ratio, median age at diagnosis is 60 y/o. 
  • Responds to steroids- often have to put on Rituximab (B-cell depleting) if refractory disease/maintenance therapy
  
  

  Posted 02/22/17 01:52:11 PM by Adam Faye

• HFpEF- 80-90% MCC is HTN
  • If someone with HFpEF does NOT have HTN (assessed on vital signs)- should prompt an immediate cardiology referral - has serious pathology and very difficult to treat
  
  

  Posted 02/22/17 01:56:20 PM by Adam Faye

Created by Christopher Kelly

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