- 7141 patients with acute heart failure; Nesiritide vs. Placebo
- Primary Endpoint- Change in dyspnea at 6 & 24hrs.
- 6hrs- 44.5% vs. 42.1% & 24hrs- 68.2% vs. 66.%1
- No difference in readmission/death/rate of worsening renal function at 30 days.
Posted 02/22/17 01:49:13 PM by Adam Faye
- Typically have high serum IgG4 levels
- On histopathology see IgG4-positive lymphoplasmacytic infiltration, fibrosis, and obliterative phlebitis or arteritis.
- Men:Women - 3:1 likelihood ratio, median age at diagnosis is 60 y/o.
- Responds to steroids- often have to put on Rituximab (B-cell depleting) if refractory disease/maintenance therapy
Posted 02/22/17 01:52:11 PM by Adam Faye
HFpEF- 80-90% MCC is HTN
- If someone with HFpEF does NOT have HTN (assessed on vital signs)- should prompt an immediate cardiology referral - has serious pathology and very difficult to treat
Posted 02/22/17 01:56:20 PM by Adam Faye
Created by Christopher Kelly
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