Osteogenic Sarcoma- Most Commonly in long bones (knee, shoulder)
- MC bone tumor
- Usually with distant mets - high survival rate
- Sun-burst appearance on radiography
- Onion skinning appearance on radiography
- Small round blue cell
- Translocation 11/22
Posted 02/21/17 10:28:56 AM by Adam Faye
- Chordomas are rare (1/1,000,000), slow growing, locally aggressive neoplasms of bone that arise from embryonic remnants of the notochord.
- These tumors typically occur in the axial skeleton and are most common in the sphenooccipital region of the skull base and in the sacral regions.
- In adults, 50 percent of chordomas involve the sacrococcygeal region, 35 percent occur at the base of the skull, and 15 percent are found elsewhere in the vertebral column.
- Initial Rx is surgical resection followed by radiation therapy if complete resection isn’t possible.
- Tumors are slow growing; Locally invasive with high incidence of local recurrence -> death due to uncontrolled local disease.
- Addition of radiation improves disease-free survival if unable to fully resected.
Columbia Combined Cancer Panel:
- Looks at over 400 common gene mutations; Almost 100 have targetable therapies.
Posted 02/21/17 10:38:21 AM by Adam Faye
Created by Christopher Kelly
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