• Osteogenic Sarcoma- Most Commonly in long bones (knee, shoulder)
  • MC bone tumor
  • Usually with distant mets - high survival rate
  • Sun-burst appearance on radiography
  Ewing's Sarcoma
  • Onion skinning appearance on radiography
  • Small round blue cell
  • Translocation 11/22
  
  

  Posted 02/21/17 10:28:56 AM by Adam Faye

• Chordoma:
  • Chordomas are rare (1/1,000,000), slow growing, locally aggressive neoplasms of bone that arise from embryonic remnants of the notochord.
  • These tumors typically occur in the axial skeleton and are most common in the sphenooccipital region of the skull base and in the sacral regions. 
  • In adults, 50 percent of chordomas involve the sacrococcygeal region, 35 percent occur at the base of the skull, and 15 percent are found elsewhere in the vertebral column. 
  
  Treatment:
  • Initial Rx is surgical resection followed by radiation therapy if complete resection isn’t possible.
  • Tumors are slow growing; Locally invasive with high incidence of local recurrence -> death due to uncontrolled local disease.
  • Addition of radiation improves disease-free survival if unable to fully resected. 
  
  Columbia Combined Cancer Panel:
  • Looks at over 400 common gene mutations; Almost 100 have targetable therapies.
  
  

  Posted 02/21/17 10:38:21 AM by Adam Faye

Created by Christopher Kelly
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