Older woman presenting w/ thyroiditis and nephrotic-range proteinuria, found to have MCD
Dr. Jai Radhakrishnan | Morning Report | 11/29/2016
Correlation between spot UPro/Cr ratio and 24 hour urine? --> moderate accuracy (R 0.8)
Still very useful for clinical practice, limitation is mostly for research purposes (UPro < 3g is often treatment goal)
Posted 11/29/16 09:09:54 AM by Matthew Cummings
Renal US for the assessment of chronic kidney disease chronicity?
US can help assess for chronicity if kidneys are SMALL in size (echogenicity is less reliable)
Posted 11/29/16 09:11:41 AM by Matthew Cummings
Concern for plasma cell disorder/amyloidosis and associated renal disease?
Must send serum free light chains (SFLC) -- can detect the low levels of FLCs (may be below threshold detected by SPEP/UPEP) AND SFLC can detect changes in kappa/lambda ratio (excess plasma cell clone)
Posted 11/29/16 09:16:43 AM by Matthew Cummings
Nephrotic syndrome in African-American population:
FSGS (#1 in African Americans -- also think FSGS due to HIV, viral hepatitis)