Higher likelihood of syphilis in CNS in HIV patients with CD4<350 or RPR > 1:32
CSF VDRL --> Specific but NOT Sensitive
CSF FAT-ABS --> Sensitive but NOT Specific
Posted 10/18/16 03:05:45 PM by Adam Faye
The Jarisch-Herxheimer reaction is an acute febrile reaction that usually occurs within the first 24 hours after any therapy for syphilis (endotoxin release). The fever may be accompanied by headache, myalgias, rigors, sweating, hypotension, and the worsening of rash if initially present.
Posted 10/18/16 03:05:57 PM by Adam Faye
Repeat Serologies -> decrease 4-fold (2 dilutions) by :
6-12 months for Primary, Secondary, or Early Latent
12-24 months for Late Latent/Unknown Duration
Neurosyphillis – CSF studies q6months (WBC/Protein should decline, but VDRL may remain reactive for 2 years)
Posted 10/18/16 03:07:06 PM by Adam Faye
Created by Christopher Kelly
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