• NSAIDs Inhibit prostaglandin release (prostaglandins dilate the Afferent arteriole). Can cause:
  1.  AIN
  2. ATN (especially with volume depletion)
  3. Papillary Necrosis
  4. Membranous/Minimal Change
  
  

  Posted 10/06/16 10:56:13 AM by Adam Faye

• Nephritic: Injury/Inflammation of glomeruli which allows proteins, erythrocytes and leukocytes to pass through. Typical triad:
  1.  Hypertension (abnormal bp regulation)
  2.  Azotemia
  3.  Red Cell Casts
  
  
  
  

  Posted 10/06/16 10:59:22 AM by Adam Faye

• Glomerulonephritis Low Complement:
  • SLE
  • Post-infectious 
  • Endocarditis
  • Cryogloublinemia
  • MPGN
  If normal complement GN
  1. Systemic - HSP, ANCA, Goodpasture's, vasculitis
  2. Renal only- Post-infectious GN, MPGN
  
  

  Posted 10/06/16 11:05:44 AM by Adam Faye

• Acidosis in Renal Failure:
  • Non-Gap: Ammoniagenesis is impaired
  • Gap: Result of sulfate/phosphate buildup
  
  

  Posted 10/06/16 11:06:43 AM by Adam Faye

• ESRD:
  • Major cause of death is increased CV risk
    • BP control is protective 
    • Data shows BP at HD is poor predictor of prognosis. Better to use home BP recordings
    • Lipid data has been conflicting - this cochrane review showed little to no benefit in CV events
  
  

  Posted 10/06/16 11:27:32 AM by Adam Faye

Created by Christopher Kelly

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